Tissue sheets improve diabetic wound healing!
Dr. Liu Li, Project Associate Professor and Dr. Li Junjun, Project Assistant Professor in the Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, have developed a tissue sheet designed using human umbilical cord-derived mesenchymal stem cells.
have developed a tissue sheet designed using human umbilical cord-derived mesenchymal stem cells.
We would like to thank them for providing us with the outline and the paper.
We are very grateful for the use of our NF-103 for this development.
Diabetic foot ulcers are a common chronic diabetic complication. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) are widely used in regenerative medicine due to their pluripotency and availability. We have developed a poly (lactic acid-glycolic acid copolymer) (PLGA)-based scaffold for the preparation of hUC-MSC tissue sheets. In vitro immunostaining showed that hUC-MSC tissue sheets form thick, solid tissue sheets rich in extracellular matrix (ECM). Diabetic wounds in mice treated with or without hUC-MSC tissue sheets, hUC-MSC injections, or fibers revealed that hUC-MSC tissue sheet transplantation only promotes diabetic wound healing by improving re-epithelialization, collagen deposition, vessel formation and maturation . and reduced inflammation compared to that observed in other groups. Taken together, our findings suggest that hUC-MSCs cultured on PLGA scaffolds improve diabetic wound healing, collagen deposition, and angiogenesis, providing a novel and effective method for cell transplantation and a promising alternative for diabetic skin wound treatment.